Permitted under conditionsAnx. IIIRef. III/374

DAIDZEIN

SKIN CONDITIONING - MISCELLANEOUS

CAS
486-66-8
EC
207-635-4
IUPAC
—
Max conc.
0,02 %

Last CosIng update

4 April 2024

Description

Daidzein is an isoflavone, characterized by a benzopyrone structure substituted with hydroxyl groups. It is also identified by the names Daidzeol and 4',7-Dihydroxyisoflavone. Its declared technical function in the European inventory is SKIN CONDITIONING - MISCELLANEOUS, that is, skin conditioner within the category of miscellaneous agents.

Under Regulation (EC) No 1223/2009 on cosmetic products, this substance is incorporated in Annex III, which groups the substances that cosmetic products must not contain except subject to the restrictions laid down, under reference 374. The maximum authorized concentration in the ready-for-use product is "0,02 %". The conditions associated with this entry state that "From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market." No additional mandatory labelling warnings have been set specifically linked to this entry, nor restrictions by type of cosmetic product. The substance has no CMR classification under Regulation (EC) No 1272/2008.

The information presented is for technical reference only and does not constitute a recommendation for use or an efficacy claim.

Detailed EU regulation

%

Maximum permitted concentration

0,02 %

§

Regulatory framework

Regulation (EC) No 1223/2009 — Annex III, ref. 374

Last update reflected in the database: 4 April 2024

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Conditions of use

From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market.

Recent analyses mentioning this ingredient

  • SeguimientoOpinión científica SCCS (versión final con corrigendum) · 23 de septiembre de 2022
    Genistein and Daidzein

    El SCCS concluye, en la opinión SCCS/1641/22 (versión final adoptada el 16 de septiembre de 2022, con corrigendum del 11 de octubre de 2022), que la genisteína es segura en productos cosméticos hasta una concentración máxima de 0,007 % y que la daidzeína es segura hasta 0,02 %. La evaluación se basa en las formas aglicona de ambas isoflavonas y considera sus posibles propiedades de disrupción endocrina. El corrigendum corrige la biodisponibilidad por vía oral de la daidzeína a 25 % en el cálculo del margen de seguridad. Las preguntas 2 y 3 del mandato (concentración máxima alternativa y otras preocupaciones científicas) no reciben una respuesta adicional.

Data source: Official CosIng from the European Commission, updated on 4 April 2024. Learn more →